About: Monophosphoryl Lipid A     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Monophosphoryl Lipid A
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Lipid
  • Pharmacologic Substance
Preferred_Name
  • Monophosphoryl Lipid A
UMLS_CUI
  • C0066776
CAS_Registry
  • 88598-53-2
FDA_UNII_Code
  • MWC0ET1L2P
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 732707
PDQ_Closed_Trial_Search_ID
  • 732707
Chemical_Formula
  • C96H181N2O21P
FULL_SYN
  • Monophosphoryl Lipid APTNCI
  • MONOPHOSPHORYL LIPID APTFDAMWC0ET1L2P
  • 3-Deacylated Monophosphoryl Lipid ASNNCI
  • MPLABNCI
  • 3-O-Desacyl-4'-Monophosphoryl Lipid ASNNCI
  • MPLAABNCI
DEFINITION
  • A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity. As a vaccine adjuvant, monophosphoryl lipid A (MPLA) stimulates both cellular and humoral responses to the vaccine antigen. Compared to LPS, MPLA exerts a similar immunostimulatory activity but with reduced toxicity.NCI
code
  • C87754
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