About: Sulopenem Etzadroxil

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Attributes	Values
rdf:type	Class
rdfs:label	Sulopenem Etzadroxil
rdfs:subClassOf	Monobactams
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Sulopenem Etzadroxil
UMLS_CUI	C2981328
CAS_Registry	1000296-70-7
FDA_UNII_Code	492M3I304T
Contributing_Source	FDA
Chemical_Formula	C19H27NO7S3
FULL_SYN	SULOPENEM ETZADROXILPTFDA492M3I304T Methylene 2-Ethylbutanoate (5R,6S)-6-((1R)-1-Hydroxyethyl)-7-Oxo-3-(((1R,3S)-1-Oxotetrahydro-1H-1.lambda.(Sup 4)-Thiophen-3-yl)Sulfanyl)-4-Thia-1-Azabicyclo(3.2.0)Hept-2-Ene-2-CarboxylateSNNCI 4-Thia-1-Azabicyclo(3.2.0)Hept-2-Ene-2-Carboxylic Acid, 6-((1R)-1-Hydroxyethyl)-7-Oxo-3-(((1R,3S)-Tetrahydro-1-Oxido-3-Thienyl)Thio)-, (2-Ethyl-1-Oxobutoxy)Methyl Ester, (5R,6S)-SNNCI Sulopenem EtzadroxilPTNCI PF-03709270CNNCI
DEFINITION	An orally available ester prodrug form of sulopenem, a thiopenem with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. After oral administration of sulopenem etzadroxil, the ester bond is cleaved, releasing active sulopenem. Sulopenem is not active against Pseudomonas aeruginosa. In addition, this agent is fairly stable against hydrolysis by various beta-lactamases.NCI
code	C87678

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