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AttributesValues
rdf:type
rdfs:label
  • Telavancin Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Telavancin Hydrochloride
UMLS_CUI
  • C2730005
CAS_Registry
  • 560130-42-9
FDA_UNII_Code
  • 0701472ZG0
Contributing_Source
  • FDA
Chemical_Formula
  • C80H106Cl2N11O27P.HCl
FULL_SYN
  • Telavancin HydrochloridePTNCI
  • TELAVANCIN HYDROCHLORIDEPTFDA0701472ZG0
  • Vancomycin, N(Sup 3'')-(2-(Decylamino)Ethyl)-29-(((Phosphonomethyl)Amino)Methyl)-, MonohydrochlorideSNNCI
  • TD-6424CNNCI
DEFINITION
  • The hydrochloride salt form of telavancin, a lipoglycopeptide and a semisynthetic derivative of vancomycin with antibacterial activity against gram-positive bacteria. Like vancomycin, telavancin binds tightly to the D-alanyl-D-alanine residue of cell wall precursors, thereby interfering with bacterial cell wall synthesis. In addition, the lipophilic moiety of telavancin may interact with the lipid bilayer in the bacterial cell membrane, thereby compromising the integrity of cell membrane and causing cell membrane depolarization. This novel mechanism of action may contribute to telavancin's rapid bactericidal activity and its improved activity over vancomycin against some antibiotic resistance gram-positive bacteria.NCI
code
  • C87636
sameAs
is Has_Salt_Form of
is sameAs of
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