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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dienogest
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dienogest
UMLS_CUI
  • C0057916
CAS_Registry
  • 65928-58-7
FDA_UNII_Code
  • 46M3EV8HHE
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 743773
PDQ_Closed_Trial_Search_ID
  • 743773
Chemical_Formula
  • C20H25NO2
FULL_SYN
  • 19-Norpregna-4,9-Diene-21-Nitrile, 17-Hydroxy-3-Oxo-, (17.Alpha.)-SNNCI
  • MJR-35CNNCI
  • DIENOGESTPTFDA46M3EV8HHE
  • M 18575CNNCI
  • STS 557CNNCI
  • ZK 37659CNNCI
  • 17-Hydroxy-3-Oxo-19-Nor-17.Alpha.-Pregna-4,9-Diene-21-NitrileSNNCI
  • DienogestPTNCI
DEFINITION
  • An orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive. Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the expression of target genes. Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium. In addition, dienogest appears to suppress the expression of cell cycle regulator cyclin D1. Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma.NCI
code
  • C87238
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