About: Akt Inhibitor SR13668     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Akt Inhibitor SR13668
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Akt Inhibitor SR13668
NCI_META_CUI
  • CL412317
PDQ_Open_Trial_Search_ID
  • 642606
PDQ_Closed_Trial_Search_ID
  • 642606
FULL_SYN
  • SRI13668CNNCI
  • Akt Inhibitor SR13668PTNCI
DEFINITION
  • An orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.NCI
code
  • C85448
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