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AttributesValues
rdf:type
rdfs:label
  • Sulindac
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sulindac
UMLS_CUI
  • C0038792
CAS_Registry
  • 38194-50-2
Accepted_Therapeutic_Use_For
  • Arthritis; inflammatory conditions
In_Clinical_Trial_For
  • Colorectal cancer, preventive; desmoid tumor
FDA_UNII_Code
  • 184SNS8VUH
Contributing_Source
  • FDA
ALT_DEFINITION
  • A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41538
PDQ_Closed_Trial_Search_ID
  • 41538
Chemical_Formula
  • C20H17FO3S
Legacy_Concept_Name
  • Sulindac
CHEBI_ID
  • CHEBI:9352
FULL_SYN
  • Novo-SundacFBNCI
  • SULINDACPTFDA184SNS8VUH
  • SudacFBNCI
  • MK-231CNNCI
  • ReumylFBNCI
  • cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acidSNNCI
  • Sulindac SulfoxideSYNCI
  • AflodacBRNCI
  • ImbaralFBNCI
  • SulinolFBNCI
  • sulindacPTNCI-GLOSSCDR0000045372
  • ArtribidFBNCI
  • SulindacPTNCI
  • ClinorilBRNCI
  • ReumofilFBNCI
  • SulreumaFBNCI
  • (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acidSNNCI
  • Apo-SulinFBNCI
  • AlgocetilFBNCI
  • ClisundacFBNCI
  • CitireumaFBNCI
  • SulindacPTDCP00516
  • ArthrocineFBNCI
DEFINITION
  • A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)NCI
code
  • C850
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