About: Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201
NCI_META_CUI
  • CL412376
PDQ_Open_Trial_Search_ID
  • 648549
PDQ_Closed_Trial_Search_ID
  • 648549
FULL_SYN
  • Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201PTNCI
  • CV9201CNNCI
DEFINITION
  • A non-small cell lung cancer (NSCLC) vaccine containing modified mRNAs encoding cancer-testis antigen NY-ESO-1, melanoma-associated antigens C1 (MAGE-C1/CT7) and C2 (MAGE-C2/CT10), survivin, and the oncofetal antigen 5T4 with potential antitumor and immunomodulatory activities. Upon subcutaneous administration, non-small cell lung cancer mRNA-derived vaccine CV9201 may stimulate the immune system to mount a cytotoxic, antigen-specific T lymphocyte response (CTL) against NSCLC cells. The modified mRNAs in this vaccine are taken up by cells after injection and exhibit enhanced translational potency. The five tumor-associated antigens (TAAs) encoded by these mRNAs are frequently expressed by NSCLC cells.NCI
code
  • C84872
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