About: dHER2 Vaccine+AS15 Adjuvant     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • dHER2 Vaccine+AS15 Adjuvant
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • dHER2 Vaccine+AS15 Adjuvant
NCI_META_CUI
  • CL412425
PDQ_Open_Trial_Search_ID
  • 652800
PDQ_Closed_Trial_Search_ID
  • 652800
FULL_SYN
  • dHER2 Vaccine+AS15 AdjuvantPTNCI
DEFINITION
  • A cancer vaccine consisting of a truncated recombinant HER2/neu peptide (dHER2) combined with the immunoadjuvant AS15 with potential immunostimulatory and antineoplastic activities. Upon administration, dHER2+AS15 vaccine may stimulate the host immune response to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells that overexpress the HER2/neu protein, resulting in tumor cell lysis. The tumor-associated antigen (TAA) HER2/neu is often overexpressed by a variety of tumor cell types; dHER2 includes amino acids 1-645 or 1-653 of the extracellular domain (ECD) and an immunogenic carboxyl terminal autophosphorylation portion of the intracellular domain (ICD). AS15 is an adjuvant formulation that contains the adjuvant systems AS01B and AS07A; AS01 B is composed of liposomes containing 3D-MPL and QS21 and AS07A is composed of the synthetic oligodeoxynucleotide (ODN) Toll-like receptor-9 (TLR9) agonist CpG 7909.NCI
code
  • C84861
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