About: Streptozocin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Streptozocin
rdfs:subClassOf	Nitrosourea Compounds
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Streptozocin
NSC_Code	85998
UMLS_CUI	C0038432
CAS_Registry	18883-66-4
Accepted_Therapeutic_Use_For	Carcinoid tumor and syndrome; Colorectal cancer, palliative; Hodgkin's disease; Metastatic islet cell carcinoma of the pancreas
In_Clinical_Trial_For	Adrenocortical carcinoma
FDA_UNII_Code	5W494URQ81
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42831
PDQ_Closed_Trial_Search_ID	42831
Chemical_Formula	C8H15N3O7
Legacy_Concept_Name	Streptozocin
CHEBI_ID	CHEBI:9288
FULL_SYN	STREPTOZOCINPTFDA5W494URQ81 StreptozocinPTNCI U 9889SYDTPNSC0085998 U-9889SYDTPNSC0085998 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranoseSNNCI StreptozotocinSYNCI STZABNCI streptozocinPTNCI-GLOSSCDR0000045561 ZanosarSYDTPNSC0085998 U-9889CNNCI ZanosarBRNCI StreptozotocinPTDCP00238 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranoseSYDTPNSC0085998 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranoseSNNCI
DEFINITION	A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)NCI
code	C845
sameAs	STREPTOZOCIN STREPTOZOCIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0020600
is someValuesFrom of	nodeID://b651106 nodeID://b651131 nodeID://b657701 nodeID://b662981 nodeID://b667489 nodeID://b667698 nodeID://b667699 nodeID://b673728 nodeID://b673730 nodeID://b674113 nodeID://b674139 nodeID://b674146
is sameAs of	STREPTOZOCIN STREPTOZOCIN STREPTOZOCIN

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