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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Streptonigrin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Streptonigrin
NSC_Code
  • 45383
  • 83950
UMLS_CUI
  • C0038427
CAS_Registry
  • 3930-19-6
FDA_UNII_Code
  • 261Q3JB310
Contributing_Source
  • FDA
ALT_DEFINITION
  • Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39703
PDQ_Closed_Trial_Search_ID
  • 39703
Chemical_Formula
  • C25H22N4O8
Legacy_Concept_Name
  • Streptonigrin
CHEBI_ID
  • CHEBI:9287
FULL_SYN
  • BruneomycinSYDTPNSC0083950
  • BruneomycinSYNCI
  • 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic AcidSNNCI
  • STREPTONIGRINPTFDA261Q3JB310
  • STREPTONIGRINSYDTPNSC0045383
  • StreptonigrinPTNCI
  • RufocromomycinSYNCI
  • STNABNCI
  • 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic AcidSNNCI
  • RufocromomycinSYDTPNSC0083950
  • BA-163CNNCI
  • PC-501CNNCI
  • StreptonigrinPTDCP31698
DEFINITION
  • An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)NCI
code
  • C844
sameAs
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