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AttributesValues
rdf:type
rdfs:label
  • Lomitapide
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lomitapide
UMLS_CUI
  • C2827241
CAS_Registry
  • 182431-12-5
FDA_UNII_Code
  • 82KUB0583F
Contributing_Source
  • FDA
Chemical_Formula
  • C39H37F6N3O2
FULL_SYN
  • BMS-201038-01CNNCI
  • N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)Biphenyl-2-yl)Carbonyl)Amino)Piperidin-1-yl)Butyl)-9H-Fluorene-9-CarboxamideSNNCI
  • 9H-Fluorene-9-Carboxamide, N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)(1,1'-Biphenyl)-2-yl)Carbonyl)Amino)-1-Piperidinyl)Butyl)-SNNCI
  • LOMITAPIDEPTFDA82KUB0583F
  • AEGR-733CNNCI
  • LomitapidePTNCI
DEFINITION
  • A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B ) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited.NCI
code
  • C83891
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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