About: Lincosamide Antibiotic

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Attributes	Values
rdf:type	Class
rdfs:label	Lincosamide Antibiotic
rdfs:subClassOf	Antibiotic Protein Synthesis Inhibitor
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Lincosamide Antibiotic
UMLS_CUI	C2826567
Legacy_Concept_Name	Lincosamide_Antibiotic
FULL_SYN	Lincosamide AntibioticPTNCI
DEFINITION	Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death.NCI
code	C82922
is rdfs:subClassOf of	LINCOMYCIN LINCOMYCIN HYDROCHLORIDE Lincomycin Hydrochloride Anhydrous CLINDAMYCIN CLINDAMYCIN HYDROCHLORIDE CLINDAMYCIN PHOSPHATE CLINDAMYCIN PALMITATE HYDROCHLORIDE Pirlimycin Hydrochloride Clindamycin Hydrochloride Monohydrate Pirlimycin

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