About: Lincosamide Antibiotic     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lincosamide Antibiotic
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Lincosamide Antibiotic
UMLS_CUI
  • C2826567
Legacy_Concept_Name
  • Lincosamide_Antibiotic
FULL_SYN
  • Lincosamide AntibioticPTNCI
DEFINITION
  • Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death.NCI
code
  • C82922
is rdfs:subClassOf of
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