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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Semustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Carbohydrate
  • Pharmacologic Substance
Preferred_Name
  • Semustine
NSC_Code
  • 95441
UMLS_CUI
  • C0036637
CAS_Registry
  • 13909-09-6
FDA_UNII_Code
  • 6YY7T1T567
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43727
PDQ_Closed_Trial_Search_ID
  • 43727
Legacy_Concept_Name
  • Semustine
FULL_SYN
  • urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)SNNCI
  • Methyl CCNUSYNCI
  • 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosoureaSYDTPNSC0095441
  • urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)SNNCI
  • 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosoureaSNNCI
  • MeCCNUSYDTPNSC0095441
  • 1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosoureaSYDTPNSC0095441
  • Methyl LomustineSYNCI
  • MCCNUABNCI
  • trans-Methyl-CCNUSYNCI
  • Lomustine, MethylSYNCI
  • MeCCNUABNCI
  • SEMUSTINEPTFDA6YY7T1T567
  • trans-Methyl-CCNUSYDTPNSC0095441
  • Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)SYDTPNSC0095441
  • Lomustine, methylSYDTPNSC0095441
  • SemustinePTNCI
  • Methyl CCNUSYDTPNSC0095441
  • 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-NitrosoureaSNNCI
  • methyl-CCNUSYDTPNSC0095441
  • Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)SYDTPNSC0095441
  • semustinePTNCI-GLOSSCDR0000046772
DEFINITION
  • A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)NCI
code
  • C827
sameAs
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