About: PIM Kinase Inhibitor SGI-1776     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • PIM Kinase Inhibitor SGI-1776
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PIM Kinase Inhibitor SGI-1776
UMLS_CUI
  • C2742218
PDQ_Open_Trial_Search_ID
  • 638088
PDQ_Closed_Trial_Search_ID
  • 638088
Legacy_Concept_Name
  • Pim_Kinase_Inhibitor_SGI-1776
FULL_SYN
  • PIM Kinase Inhibitor SGI-1776PTNCI
  • SGI-1776CNNCI
DEFINITION
  • A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.NCI
code
  • C82404
http://linked.open...y/mesh/hasConcept
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