About: Autologous GM-CSF-Secreting Breast Cancer Vaccine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Autologous GM-CSF-Secreting Breast Cancer Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Autologous GM-CSF-Secreting Breast Cancer Vaccine
NCI_META_CUI
  • CL408659
PDQ_Open_Trial_Search_ID
  • 642215
PDQ_Closed_Trial_Search_ID
  • 642215
Legacy_Concept_Name
  • Autologous_GM-CSF-Secreting_Breast_Cancer_Vaccine
FULL_SYN
  • Autologous GM-CSF-Secreting Breast Cancer VaccinePTNCI
DEFINITION
  • An autologous tumor cell vaccine containing irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Autologous breast cancer cells are transduced ex vivo with an adenovirus vector encoding the GM-CSF gene and irradiated and then reintroduced into the patient. Upon repeated subcutaneous administration of the vaccine, autologous GM-CSF-secreting breast cancer cells secrete GM-CSF, which may stimulate a tumor-specific cytotoxic T-lymphocyte (CTL) response.NCI
code
  • C82388
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