About: Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207
NCI_META_CUI
  • CL408647
PDQ_Open_Trial_Search_ID
  • 641167
PDQ_Closed_Trial_Search_ID
  • 641167
Legacy_Concept_Name
  • Recombinant_Saccharomyces_Cerevisia-CEA_610D_Expressing_Vaccine_GI-6207
FULL_SYN
  • Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207PTNCI
  • GI-6207CNNCI
DEFINITION
  • A whole, heat-killed, recombinant Saccharomyces cerevisiae yeast-based vaccine genetically altered to express the carcinoembryonic antigen (CEA) peptide 610D with potential immunostimulating and antineoplastic activities. Upon administration, recombinant Saccharomyces cerevisia-CEA(610D) vaccine GI-6207 may stimulate a host cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells, which may result in tumor cell lysis. CEA, a tumor associated antigen, is overexpressed on a wide variety of human cancer cells including colorectal, gastric, lung, breast and pancreatic cancer cells. CEA 610D encodes for 9 amino acids (605-613) in which aspartate is substituted for asparagine at position 610 (610D) in order to strengthen the induction of the CTL response against CEA-expressing tumor cells.NCI
code
  • C82371
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