About: Anti-Dll4 Monoclonal Antibody REGN421     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-Dll4 Monoclonal Antibody REGN421
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Anti-Dll4 Monoclonal Antibody REGN421
NCI_META_CUI
  • CL408645
PDQ_Open_Trial_Search_ID
  • 640973
PDQ_Closed_Trial_Search_ID
  • 640973
Legacy_Concept_Name
  • Anti-Dll4_Monoclonal_Antibody_REGN421
FULL_SYN
  • Anti-Delta-Like 4 Monoclonal Antibody REGN421SYNCI
  • Anti-Dll4 Monoclonal Antibody REGN421PTNCI
  • REGN421CNNCI
DEFINITION
  • A human monoclonal antibody directed against Delta-like ligand-4 (DLL4) with potential antineoplastic activity. Anti-DLL4 monoclonal antibody REGN421 specifically binds to human DLL4, preventing its binding to Notch receptors and inhibiting Notch signaling, which may result in defective tumor vascularization and, so, the inhibition of tumor cell growth. DLL4 is the only Notch ligand selectively expressed on endothelial cells; DLL4/Notch signaling is required for the development of functional tumor blood vessels.NCI
code
  • C82367
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