About: Aurora Kinase Inhibitor AMG 900     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Aurora Kinase Inhibitor AMG 900
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Aurora Kinase Inhibitor AMG 900
UMLS_CUI
  • C2830045
PDQ_Open_Trial_Search_ID
  • 639524
PDQ_Closed_Trial_Search_ID
  • 639524
Legacy_Concept_Name
  • Aurora_Kinase_Inhibitor_AMG_900
FULL_SYN
  • AMG 900CNNCI
  • Aurora Kinase Inhibitor AMG 900PTNCI
DEFINITION
  • A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.NCI
code
  • C82349
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