About: TLR8 Agonist VTX-2337     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TLR8 Agonist VTX-2337
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • TLR8 Agonist VTX-2337
NCI_META_CUI
  • CL388344
PDQ_Open_Trial_Search_ID
  • 599455
PDQ_Closed_Trial_Search_ID
  • 599455
Legacy_Concept_Name
  • TLR8_Agonist_VTX-2337
FULL_SYN
  • Toll-like Receptor 8 Agonist VTX-2337SYNCI
  • VTX-2337CNNCI
  • TLR8 Agonist VTX-2337PTNCI
DEFINITION
  • A small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.NCI
code
  • C80521
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