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AttributesValues
rdf:type
rdfs:label
  • Reserpine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Reserpine
PubMedID_Primary_Reference
  • 18362193
NSC_Code
  • 59272
UMLS_CUI
  • C0035179
CAS_Registry
  • 50-55-5
FDA_UNII_Code
  • 8B1QWR724A
Contributing_Source
  • FDA
ALT_DEFINITION
  • An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.MSH2002_06_01
Chemical_Formula
  • C33H40N2O9
Legacy_Concept_Name
  • Reserpine
CHEBI_ID
  • CHEBI:28487
FULL_SYN
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl EsterPTDCP01182
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl EsterSNNCI
  • RESERPINEPTFDA8B1QWR724A
  • RESERPINESYDTPNSC0059272
  • ReserpinePTNCI
DEFINITION
  • An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects.NCI
code
  • C803
sameAs
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