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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cocaine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cocaine
UMLS_CUI
  • C0009170
CAS_Registry
  • 50-36-2
FDA_UNII_Code
  • I5Y540LHVR
Contributing_Source
  • FDA
Chemical_Formula
  • C17H21NO4
Legacy_Concept_Name
  • Cocaine
CHEBI_ID
  • CHEBI:27958
FULL_SYN
  • COCAINEPTFDAI5Y540LHVR
  • CocainePTNCI
  • (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl BenzoateSNNCI
DEFINITION
  • A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.NCI
code
  • C80153
sameAs
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