About: Retinoid 9cUAB30     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Retinoid 9cUAB30
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Retinoid 9cUAB30
UMLS_CUI
  • C1311390
ALT_DEFINITION
  • A substance being studied in the treatment and prevention of cancer. It blocks an enzyme that keeps cells alive by adding material to the ends of chromosomes. Blocking this enzyme may cause the cancer cells to die. 9cUAB30 is a type of retinoic acid and a type of telomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 614594
PDQ_Closed_Trial_Search_ID
  • 614594
Legacy_Concept_Name
  • Retinoid_9cUAB30
FULL_SYN
  • Retinoid 9cUAB30PTNCI
  • 9cUAB30PTNCI-GLOSSCDR0000641967
DEFINITION
  • A synthetic analogue of 9-cis retinoic acid with potential antineoplastic and chemopreventive activities. Retinoid 9cUAB30 binds to and activates retinoid X receptor (RXR) homodimers and/or and retinoic acid receptor (RAR)/RXR heterodimers, which may result in the dissociation of corepressor protein and the recruitment of coactivator protein, followed by transcription of downstream target genes into mRNAs and protein translation. Gene transcription regulated by these transcription factors may result in inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.NCI
code
  • C80061
http://linked.open...y/mesh/hasConcept
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