About: Sotatercept

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Sotatercept
rdfs:subClassOf	Immunoconjugates
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Sotatercept
UMLS_CUI	C2703199
CAS_Registry	1001080-50-7
FDA_UNII_Code	0QI90BTJ37
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	615188
PDQ_Closed_Trial_Search_ID	615188
Legacy_Concept_Name	Decoy_Activin_Receptor_ACE-011
FULL_SYN	SotaterceptPTNCI ACE-011CNNCI Decoy Activin Receptor ACE-011SYNCI SOTATERCEPTPTFDA0QI90BTJ37
DEFINITION	A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system.NCI
code	C80038
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0537365

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