About: TMPRSS2/ERG Fusion Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TMPRSS2/ERG Fusion Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • TMPRSS2/ERG Fusion Gene
UMLS_CUI
  • C1865933
Legacy_Concept_Name
  • TMPRSS2-ERG_Fusion_Gene
FULL_SYN
  • ERG/TMPRSS2 Fusion GeneSYNCI
  • TMPRSS2-ERG Fusion GeneSYNCI
  • TMPRSS2/ERG Fusion GenePTNCI
DEFINITION
  • A fusion gene that results from a genetic translocation event which fuses the 5' end of the androgen-regulated TMPRRSS2 gene with the entire coding region of the ERG gene. The androgen-dependent expression of this fusion gene results in overexpression of ERG activity.NCI
DesignNote
  • This gene fusion was the first ever discovered in a solid tumor. It is also a biomarker for Prostate Cancer. 7 October, NCI Cancer Bulletin 5, 20 (2008)
code
  • C79904
is someValuesFrom of
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