About: PPE-Expressing Replication-Defective HSV-1 Vector NP2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PPE-Expressing Replication-Defective HSV-1 Vector NP2
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PPE-Expressing Replication-Defective HSV-1 Vector NP2
NCI_META_CUI
  • CL388508
PDQ_Open_Trial_Search_ID
  • 630943
PDQ_Closed_Trial_Search_ID
  • 630943
Legacy_Concept_Name
  • PPE-Expressing_Nonreplicating_HSV-1-Based_Vector_NP2
FULL_SYN
  • PPE-Expressing Replication-Defective HSV-1 Vector NP2PTNCI
  • NP2CNNCI
  • Preproenkephalin-Expressing Replication-Defective Herpes Simplex Virus-1 Vector NP2SYNCI
DEFINITION
  • A replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector expressing the human preproenkephalin A (PPE) gene with potential antinociceptive activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1 vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion (DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with high efficiency, delivering the engineered PPE gene; transduced neurons then express the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met- and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the inhibition of nociceptive neurotransmission.NCI
code
  • C79845
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