About: Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes
NCI_META_CUI
  • CL388449
PDQ_Open_Trial_Search_ID
  • 630382
PDQ_Closed_Trial_Search_ID
  • 630382
Legacy_Concept_Name
  • Anti-CEA_TCR_Retroviral_Vector-Transduced_Autologous_Peripheral_Blood_Lymphocytes
FULL_SYN
  • Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood LymphocytesPTNCI
  • Anti-CEA TCR Retroviral Vector-Transduced Autologous PBLsSYNCI
  • Anti-CEA TCR-Gene Engineered Autologous LymphocytesSYNCI
DEFINITION
  • Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung, and breast.NCI
code
  • C79842
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