About: Light-Emitting Oncolytic Vaccinia Virus GL-ONC1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Light-Emitting Oncolytic Vaccinia Virus GL-ONC1
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Light-Emitting Oncolytic Vaccinia Virus GL-ONC1
NCI_META_CUI
  • CL388438
PDQ_Open_Trial_Search_ID
  • 629379
PDQ_Closed_Trial_Search_ID
  • 629379
Legacy_Concept_Name
  • Light-Emitting_Oncolytic_Vaccinia_Virus_GL-ONC1
FULL_SYN
  • Light-Emitting Oncolytic Vaccinia Virus GL-ONC1PTNCI
  • GL-ONC1CNNCI
  • GLV-1h68CNNCI
DEFINITION
  • An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis and the release of mature viral particles into the tumor microenvironment. Released viral particles may then infect and destroy neighboring tumor cells. In addition, the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence imaging and fluorescence imaging techniques.NCI
code
  • C79833
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