About: Gemcitabine Elaidate

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Attributes	Values
rdf:type	Class
rdfs:label	Gemcitabine Elaidate
rdfs:subClassOf	Pyrimidine Antagonist Ribonucleotide Reductase Inhibitor nodeID://b676669 nodeID://b676670 nodeID://b676671 nodeID://b676672 nodeID://b676673
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Gemcitabine Elaidate
UMLS_CUI	C2703166
CAS_Registry	210829-30-4
FDA_UNII_Code	231C73W7LG
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	624375
PDQ_Closed_Trial_Search_ID	624375
Legacy_Concept_Name	Gemcitabine_5-Elaidic_Acid_Ester
FULL_SYN	Gemcitabine 5'-Elaidic Acid EsterSYNCI CP-4126CNNCI Gemcitabine ElaidatePTNCI GEMCITABINE ELAIDATEPTFDA231C73W7LG
DEFINITION	A lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase.NCI
code	C79803
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0533324

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