About: Anti-IGF-1R Monoclonal Antibody AVE1642     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Anti-IGF-1R Monoclonal Antibody AVE1642
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Anti-IGF-1R Monoclonal Antibody AVE1642
UMLS_CUI
  • C2703165
PDQ_Open_Trial_Search_ID
  • 619043
PDQ_Closed_Trial_Search_ID
  • 619043
Legacy_Concept_Name
  • Anti-IGF-1R_Monoclonal_Antibody_AVE1642
FULL_SYN
  • anti-CD122 monoclonal antibody AVE1642SYNCI
  • Anti-IGF-1R Monoclonal Antibody AVE1642PTNCI
  • AVE1642CNNCI
DEFINITION
  • A humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. Anti-IGF-1R monoclonal antibody AVE1642 specifically binds to and blocks membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signal transduction, which may result in the induction of apoptosis and a decrease in cellular proliferation. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.NCI
code
  • C79798
http://linked.open...y/mesh/hasConcept
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