About: Banoxantrone

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Banoxantrone Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Banoxantrone
rdfs:subClassOf	Anthraquinones
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Banoxantrone
UMLS_CUI	C0299316
CAS_Registry	136470-65-0
FDA_UNII_Code	W5H7E45YT3
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	393464
PDQ_Closed_Trial_Search_ID	393464
Chemical_Formula	C22H28N4O6
Legacy_Concept_Name	Banoxantrone
FULL_SYN	BANOXANTRONEPTFDAW5H7E45YT3 BanoxantronePTNCI 9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-, N,N'-dioxideSNNCI Aq4NCNNCI AQ 4NCNNCI
DEFINITION	A bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic and hypoxic regions of tumors can be targeted.NCI
code	C79528
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0248799

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software