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AttributesValues
rdf:type
rdfs:label
  • Quercetin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Quercetin
NSC_Code
  • 9219
UMLS_CUI
  • C0034392
CAS_Registry
  • 117-39-5
FDA_UNII_Code
  • 9IKM0I5T1E
Contributing_Source
  • CRCH
  • FDA
ALT_DEFINITION
  • A kaempferol with a hydroxyl group at C-3'.CRCH
  • A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 43114
PDQ_Closed_Trial_Search_ID
  • 43114
Chemical_Formula
  • C15H10O7
Unit
  • mg
Legacy_Concept_Name
  • Quercetin
CHEBI_ID
  • CHEBI:16243
FULL_SYN
  • QuercetinPTDCP00221
  • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-oneSYCRCH
  • 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-oneSYNCI
  • QUERCETINPTFDA9IKM0I5T1E
  • QuercetinSYDTPNSC0009219
  • 3,3',4',5,7-PentahydroxyflavoneSNNCI
  • QuercetinPTNCI
  • C.I. Natural Yellow 10SYNCI
  • QuercetinPTCRCH
DEFINITION
  • A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators.NCI
code
  • C792
sameAs
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