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AttributesValues
rdf:type
rdfs:label
  • Astuprotimut-R
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Astuprotimut-R
NCI_META_CUI
  • CL414862
CAS_Registry
  • 949885-73-8
FDA_UNII_Code
  • 50I23C5UOR
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 600553
PDQ_Closed_Trial_Search_ID
  • 600553
Legacy_Concept_Name
  • Recombinant_MAGE-A3_Antigen-Specific_Cancer_Immunotherapeutic_GSK1203486A
FULL_SYN
  • Recombinant MAGE-A3 ASCI GSK1203486AABNCI
  • ASTUPROTIMUT-RPTFDA50I23C5UOR
  • Astuprotimut-RPTNCI
  • MAGE-A3CNNCI
  • GSK1203486ACNNCI
DEFINITION
  • A cancer vaccine consisting of a recombinant form of human melanoma antigen A3 (MAGE-A3) combined with a proprietary adjuvant with potential immunostimulatory and antineoplastic activities. Upon administration, astuprotimut-R may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the MAGE-A3 antigen, resulting in tumor cell death. MAGE-A3, a tumor-associated antigen (TAA) originally discovered in melanoma cells, is expressed by various tumor types. The proprietary immunostimulating adjuvant in this agent is composed of a specific combination of immunostimulating compounds selected to increase the anti-tumor immune response to MAGE-A3.NCI
code
  • C78478
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