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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Semuloparin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Semuloparin
UMLS_CUI
  • C2703115
CAS_Registry
  • 9005-49-6
FDA_UNII_Code
  • 4QW4AN84NQ
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 599247
PDQ_Closed_Trial_Search_ID
  • 599247
Legacy_Concept_Name
  • Ultralow-Molecular-Weight_Heparin_AVE5026
CHEBI_ID
  • CHEBI:28304
FULL_SYN
  • SemuloparinPTNCI
  • Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization)SYNCI
  • AVE5026CNNCI
  • AVE-5026CNNCI
  • ULMW heparin AVE5026ABNCI
  • Ultralow-Molecular-Weight Heparin AVE5026SYNCI
  • SEMULOPARINPTFDA4QW4AN84NQ
DEFINITION
  • An ultralow-molecular-weight heparin (ULMWH) (Mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. Ultralow-molecular-weight heparin AVE5026 binds to and activates antithrombin III (ATIII), which may result in the inhibition of activated factor Xa and, to a much lesser extent, factor IIa (thrombin) and so the inhibition of fibrin formation. Compared to low-molecular-weight heparins (LMWHs), AVE5026 exhibits an even higher ratio of anti-Factor Xa to anti-Factor IIa activity (>30:1). Compared to unfractionated heparins, the use of LMWHs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. Like LMWHs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. AVE5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.NCI
code
  • C78447
http://linked.open...y/mesh/hasConcept
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