About: R-(-)-Gossypol Acetic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • R-(-)-Gossypol Acetic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • R-(-)-Gossypol Acetic Acid
UMLS_CUI
  • C1831824
CAS_Registry
  • 866541-93-7
FDA_UNII_Code
  • U9GNI6VT5N
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 594869
PDQ_Closed_Trial_Search_ID
  • 594869
Chemical_Formula
  • C30H30O8.C2H4O2
Legacy_Concept_Name
  • R-Gossypol_Acetic_Acid
FULL_SYN
  • (-)-Gossypol Acetic AcidSYNCI
  • R-(-)-Gossypol Acetic AcidPTNCI
  • AT-101CNNCI
  • GOSSYPOL ACETIC ACID, (R)-PTFDAU9GNI6VT5N
  • (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)SNNCI
DEFINITION
  • The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R-(-)-gossypol binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Racemic gossypol is a polyphenolic compound isolated from cottonseed.NCI
code
  • C78348
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