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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Propylthiouracil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Propylthiouracil
NSC_Code
  • 70461
UMLS_CUI
  • C0033511
CAS_Registry
  • 51-52-5
FDA_UNII_Code
  • 721M9407IY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39288
PDQ_Closed_Trial_Search_ID
  • 39288
Chemical_Formula
  • C7H10N2OS
Legacy_Concept_Name
  • Propylthiouracil
CHEBI_ID
  • CHEBI:8502
FULL_SYN
  • 6-Propyl-2-thiouracilSYDTPNSC0070461
  • PROPYLTHIOURACILPTFDA721M9407IY
  • PropylthiouracilPTNCI
  • PropylthiouracilSYDTPNSC0070461
  • 6-Propyl-2-ThiouracilSYNCI
DEFINITION
  • A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.NCI
code
  • C781
sameAs
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