About: Chloroquine Sulfate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chloroquine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Chloroquine Sulfate
NSC_Code
  • 292296
UMLS_CUI
  • C0700447
CAS_Registry
  • 132-73-0
FDA_UNII_Code
  • OE48649K6N
Contributing_Source
  • FDA
Chemical_Formula
  • C18H26ClN3.H2SO4
Legacy_Concept_Name
  • Chloroquine_Sulfate
CHEBI_ID
  • CHEBI:50178
FULL_SYN
  • 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Sulfate (1:1)SNNCI
  • LariagoBRNCI
  • Chloroquine SulfatePTNCI
  • MelubrinBRNCI
  • CHLOROQUINE SULFATEPTFDAOE48649K6N
  • NivaquineBRNCI
  • CisplaquinSYNCI
DEFINITION
  • The sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.NCI
code
  • C78058
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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