About: Ad-sig-hMUC-1/ecdCD40L Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ad-sig-hMUC-1/ecdCD40L Vaccine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Ad-sig-hMUC-1/ecdCD40L Vaccine
NCI_META_CUI
  • CL386701
PDQ_Open_Trial_Search_ID
  • 599246
PDQ_Closed_Trial_Search_ID
  • 599246
Legacy_Concept_Name
  • Ad-sig-hMUC-1_ecdCD40L_Vaccine
FULL_SYN
  • Ad-sig-hMUC-1/ecdCD40L Adenoviral Vector VaccineSYNCI
  • Ad-sig-hMUC-1/ecdCD40L VaccinePTNCI
DEFINITION
  • A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by Ad-sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate, T-cells may expand, and a cytotoxic T lymphocyte (CTL) response against tumor cells that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed by epithelial cancer cells.NCI
code
  • C77910
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