About: HPV DNA Plasmids Therapeutic Vaccine VGX-3100     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • HPV DNA Plasmids Therapeutic Vaccine VGX-3100
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • HPV DNA Plasmids Therapeutic Vaccine VGX-3100
NCI_META_CUI
  • CL387278
PDQ_Open_Trial_Search_ID
  • 599041
PDQ_Closed_Trial_Search_ID
  • 599041
Legacy_Concept_Name
  • HPV_DNA_Plasmids_Therapeutic_Vaccine_VGX-3100
FULL_SYN
  • HPV DNA Plasmids Therapeutic Vaccine VGX-3100PTNCI
  • VGX-3100CNNCI
DEFINITION
  • A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and antineoplastic activities. Administered via intramuscular electroporation, HPV DNA plasmids therapeutic vaccine VGX-3100 expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved in cervical carcinogenesis.NCI
code
  • C77909
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