About: Retinoid Analogue NRX 195183     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Retinoid Analogue NRX 195183
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Retinoid Analogue NRX 195183
NCI_META_CUI
  • CL383603
PDQ_Open_Trial_Search_ID
  • 596530
PDQ_Closed_Trial_Search_ID
  • 596530
Legacy_Concept_Name
  • Retinoid_Analogue_NRX_195183
FULL_SYN
  • Retinoid Acid Receptor Alpha Agonist NRX 195183SYNCI
  • RAR Alpha Agonist NRX 195183ABNCI
  • Retinoid Analogue NRX 195183PTNCI
  • NRX 195183CNNCI
DEFINITION
  • An orally bioavailable retinoid acid receptor (RAR) alpha agonist with potential antineoplastic activity. Retinoid analogue NRX 195183 binds to and activates RAR alpha, modulating the transcription of genes responsible for cell differentiation and proliferation, which may result in cell differentiation, decreased cell proliferation, and the inhibition of tumorigenesis. Encoded by the RARA gene, RAR alpha is a nuclear receptor and a member of the steroid receptor superfamily.NCI
code
  • C77899
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