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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lexibulin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lexibulin
UMLS_CUI
  • C2703082
CAS_Registry
  • 917111-44-5
FDA_UNII_Code
  • 2GTU230HA1
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 598799
PDQ_Closed_Trial_Search_ID
  • 598799
Chemical_Formula
  • C24H30N6O2
Legacy_Concept_Name
  • Tubulin_Inhibitor_CYT997
FULL_SYN
  • 1-ethyl-3-(2-methoxy-4-(5-methyl-4-(((1s)-1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)ureaSNNCI
  • Tubulin Inhibitor CYT997SYNCI
  • CYT997CNNCI
  • LEXIBULINPTFDA2GTU230HA1
  • LexibulinPTNCI
DEFINITION
  • An orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.NCI
code
  • C77882
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