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AttributesValues
rdf:type
rdfs:label
  • Oral Milataxel
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oral Milataxel
NCI_META_CUI
  • CL387339
PDQ_Open_Trial_Search_ID
  • 597742
PDQ_Closed_Trial_Search_ID
  • 597742
Legacy_Concept_Name
  • Oral_Milataxel
FULL_SYN
  • Oral MilataxelPTNCI
  • TL139CNNCI
  • TL-00139CNNCI
DEFINITION
  • An orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.NCI
code
  • C77880
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