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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Natalizumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Natalizumab
UMLS_CUI
  • C0665297
CAS_Registry
  • 189261-10-7
Accepted_Therapeutic_Use_For
  • multiple sclerosis, Crohn's disease
FDA_UNII_Code
  • 3JB47N2Q2P
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 596513
PDQ_Closed_Trial_Search_ID
  • 596513
Legacy_Concept_Name
  • Natalizumab
FULL_SYN
  • NatalizumabPTNCI
  • Anti-alph4 Integrin Monoclonal Antibody AN100226SYNCI
  • TysabriBRNCI
  • AN100226CNNCI
  • AntegrenBRNCI
  • Anti-VLA4ABNCI
  • NATALIZUMABPTFDA3JB47N2Q2P
DEFINITION
  • A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with immunomodulating, anti-inflammatory, and potential antineoplastic activities. Natalizumab binds to the alpha4-subunit of alpha4beta1 and alpha4beta7 integrins expressed on the surface of all leukocytes except neutrophils, inhibiting the alpha4-mediated adhesion of leukocytes to counter-receptor(s) such as vascular cell adhesion molecule-1 (VCAM-1); natalizumab-mediated disruption of VCAM-1 binding by these integrins may prevent the transmigration of leukocytes across the endothelium into inflamed parenchymal tissue. Integrins are cellular adhesion molecules (CAMs) that are upregulated in various types of cancer and some autoimmune diseases; alpha4beta1 integrin (VLA4) has been implicated in the survival of myeloma cells, possibly by mediating their adhesion to stromal cells.NCI
code
  • C77862
sameAs
http://linked.open...y/mesh/hasConcept
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