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AttributesValues
rdf:type
rdfs:label
  • Therapeutic Progesterone
rdfs:subClassOf
Concept_In_Subset
Is_Related_To_Endogenous_Product
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Therapeutic Progesterone
NSC_Code
  • 64377
  • 9704
UMLS_CUI
  • C0591309
CAS_Registry
  • 57-83-0
Accepted_Therapeutic_Use_For
  • Amenorrhea; Functional uterine bleeding; Infertility; Maintenance of pregnancy
In_Clinical_Trial_For
  • Menopausal symptoms, in patients with history of breast cancer
FDA_UNII_Code
  • 4G7DS2Q64Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • The principal progestational hormone of the body, secreted by the corpus luteum, adrenal cortex, and placenta. Its chief function is to prepare the uterus for the reception and development of the fertilized ovum. It acts as an antiovulatory agent when administered on days 5-25 of the menstrual cycle.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39059
PDQ_Closed_Trial_Search_ID
  • 39059
Chemical_Formula
  • C21H30O2
Legacy_Concept_Name
  • Therapeutic_Progesterone
CHEBI_ID
  • CHEBI:17026
  • CHEBI:59826
FULL_SYN
  • PROGESTERONEPTFDA4G7DS2Q64Y
  • Lutocylin MFBNCI
  • ProgestogelFBNCI
  • LuteohormoneSYDTPNSC0009704
  • ProgestasertSYDTPNSC0009704
  • SyngesteroneSYDTPNSC0009704
  • ProgestasertFBNCI
  • LuteohormoneBRNCI
  • ProgesteroneSYNCI
  • SyngesteroneFBNCI
  • Therapeutic ProgesteronePTNCI
  • Delta4-pregnene-3,20-dioneSNNCI
  • Corpus luteum hormoneSYDTPNSC0009704
  • GestoneSYDTPNSC0009704
  • LutogylSYDTPNSC0009704
  • ProgesteronePTDCP00451
  • ProlidonSYDTPNSC0009704
  • ProlutonSYDTPNSC0009704
  • GestoneFBNCI
  • LutogylFBNCI
  • CyclogestSYDTPNSC0009704
  • CorlutinaSYDTPNSC0009704
  • ProgestinSYDTPNSC0009704
  • CorluviteSYDTPNSC0009704
  • LutromoneSYDTPNSC0009704
  • ProlidonFBNCI
  • GestironFBNCI
  • ProlutonBRNCI
  • Lipo-LutinSYDTPNSC0009704
  • LutocyclinSYDTPNSC0009704
  • 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dioneSNNCI
  • UtrogestanSYDTPNSC0009704
  • CyclogestFBNCI
  • CorlutinaFBNCI
  • CorluviteFBNCI
  • ProgestinBRNCI
  • ProgestolFBNCI
  • ProgestonFBNCI
  • LutromoneFBNCI
  • Lipo-LutinBRNCI
  • LutocyclinFBNCI
  • UtrogestanFBNCI
DEFINITION
  • A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. (NCI04)NCI
code
  • C777
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