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AttributesValues
rdf:type
rdfs:label
  • Probenecid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Probenecid
NSC_Code
  • 18786
UMLS_CUI
  • C0033209
CAS_Registry
  • 57-66-9
FDA_UNII_Code
  • PO572Z7917
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat gout and is used together with some antibiotics to make them work better. It is being studied in the treatment of cancer. It belongs to the family of drugs called antibiotic therapy adjuncts.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40223
PDQ_Closed_Trial_Search_ID
  • 40223
Chemical_Formula
  • C13H19NO4S
Legacy_Concept_Name
  • Probenecid
FULL_SYN
  • probenecidPTNCI-GLOSSCDR0000045288
  • SK-ProbenecidBRNCI
  • BenemidSYDTPNSC0018786
  • PROBABNCI
  • BenemidBRNCI
  • PROBENECIDPTFDAPO572Z7917
  • ProbenecidSYDTPNSC0018786
  • ProbenecidPTNCI
DEFINITION
  • A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.NCI
code
  • C772
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