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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oteracil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oteracil
UMLS_CUI
  • C0030032
CAS_Registry
  • 937-13-3
FDA_UNII_Code
  • 5VT6420TIG
Contributing_Source
  • FDA
Chemical_Formula
  • C4H3N3O4
Legacy_Concept_Name
  • Oteracil
CHEBI_ID
  • CHEBI:30863
FULL_SYN
  • Oxonic AcidSYNCI
  • OTERACILPTFDA5VT6420TIG
  • OteracilPTNCI
DEFINITION
  • A modulator of 5-fluorouracil (5-FU) activity and inhibitor of the enzyme orotate phosphoribosyl-transferase (OPRT), with chemoprotective activity. Oteracil preferentially localizes in the gastrointestinal (GI) tract where it inhibits OPRT, thereby decreasing metabolism of 5-FU into its active metabolite 5-fluorouridine-5'-monophosphate (FUMP). This decreases activated 5-FU-related gastrointestinal toxicity.NCI
code
  • C76917
sameAs
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