About: Z, Rat Strain     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Z, Rat Strain
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Mammal
Preferred_Name
  • Z, Rat Strain
UMLS_CUI
  • C2700303
Contributing_Source
  • CDISC
ALT_DEFINITION
  • Derived from a spontaneous mutation in the leptin receptor that appeared in a 13M rat colony bred at the Zucker Laboratory of Comparative Pathology (Stow, MA), genotype leprfa.CDISC
Legacy_Concept_Name
  • Z_Rat_Strain
FULL_SYN
  • Z, Rat StrainPTNCI
  • ZuckerSYNCI
  • ZUCKERPTCDISC
DEFINITION
  • Derived from a spontaneous mutation in the leptin receptor that appeared in a 13M rat colony bred at the Zucker Laboratory of Comparative Pathology (Stow, MA), genotype leprfa. The Zucker rat may come in four principal color variants, including brown, brown and white, black, and black and white. The mutation causes severe obesity, diabetes, abnormal heart function, hypertriglyceridemia, and hypercholesterolemia. The Zucker rat is utilized in biomedical research to study insulin resistance, glucose intolerance, metabolic syndromes, and obesity.NCI
code
  • C76194
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