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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cilazaprilat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cilazaprilat
UMLS_CUI
  • C0055724
CAS_Registry
  • 90139-06-3
FDA_UNII_Code
  • WBL76FH528
Contributing_Source
  • FDA
Chemical_Formula
  • C20H27N3O5
Legacy_Concept_Name
  • Cilazaprilat
FULL_SYN
  • CILAZAPRILATPTFDAWBL76FH528
  • CilazaprilatPTNCI
DEFINITION
  • The active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C75927
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