About: Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001
NCI_META_CUI
  • CL384120
PDQ_Open_Trial_Search_ID
  • 673240
PDQ_Closed_Trial_Search_ID
  • 673240
Legacy_Concept_Name
  • Attenuated_Live_Listeria_Encoding_HPV_16_E7_Vaccine
FULL_SYN
  • Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001PTNCI
  • Lm-LLO-E7SYNCI
  • Attenuated Live Listeria Encoding HPV 16 E7 VaccineSYNCI
  • Lovaxin-CSYNCI
  • ADXS11-001CNNCI
  • Attenuated Live Listeria Encoding Human Papilloma Virus 16 E7 VaccineSYNCI
DEFINITION
  • A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination, Listeria expresses the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical cancer cells.NCI
code
  • C74595
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