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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Codeine Phosphate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Codeine Phosphate
UMLS_CUI
  • C0009217
CAS_Registry
  • 41444-62-6
FDA_UNII_Code
  • GSL05Y1MN6
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat pain, cough, and diarrhea. It is made from opium or morphine and binds to opioid receptors in the central nervous system. Codeine phosphate is a type of opiate, a type of analgesic agent, a type of antitussive agent, and a type of antidiarrheal agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40563
PDQ_Closed_Trial_Search_ID
  • 40563
Chemical_Formula
  • 2C18H21NO3.H2O.2H3O4P
Legacy_Concept_Name
  • Codeine_Phosphate
FULL_SYN
  • codeine phosphatePTNCI-GLOSSCDR0000546735
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-alpha)-, phosphateSNNCI
  • Codeine PhosphatePTNCI
  • CODEINE PHOSPHATEPTFDAGSL05Y1MN6
  • TricodeinSYNCI
DEFINITION
  • The phosphate salt of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities. Codeine mimics the actions of endogenous opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of mu-subtype opioid receptors results in a decrease in the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the codeine metabolite morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability. Stimulation of gut mu-subtype opioid receptors results in a reduction in intestinal motility and delayed intestinal transit times. Antitussive activity is mediated through codeine's action on the cough center in the medulla.NCI
code
  • C74548
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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