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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mixed Bacteria Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mixed Bacteria Vaccine
NCI_META_CUI
  • CL383537
PDQ_Open_Trial_Search_ID
  • 590146
PDQ_Closed_Trial_Search_ID
  • 590146
Legacy_Concept_Name
  • Mixed_Bacteria_Vaccine
FULL_SYN
  • Mixed Bacteria VaccinePTNCI
  • Coley's ToxinSYNCI
  • MBVABNCI
DEFINITION
  • A cancer vaccine containing a mixture of killed bacteria with potential immunostimulatory and antineoplastic activities. Mixed bacteria vaccine (MBV or Coley's toxins) consists of a pyrogenic bacterial lysate derived from Serratia marcescens and Streptococcus pyogenes; the active components in the lysate may be lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall of Serratia, and streptokinase, an enzyme produced by Streptococcus pyogenes. LPS has been shown to stimulate the host humoral immune response and induce the release of various antitumor cytokines such as tumor necrosis factor (TNF) and interleukin-12 (IL-12).NCI
code
  • C74063
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